Endocrine Abstracts

Introduction: Hypoparathyroidism is one of the most common complications following thyroidectomy and it is associated with significant morbidity. It usually occurs within the first 48 h after thyroid surgery, however hypocalcemia symptoms may only begin up to 64 h after surgery. Therefore, early detection of hypoparathyroidism is essential to a secure postsurgery discharge.Objectives: We aimed to evaluate the potential risk factors for postsurgical hypop...

Introduction: Diabetes mellitus (DM) is a chronic disease with increasing incidence worldwide, mostly in younger ages. Diabetic kidney disease (DKD) is a main complication, with a prevalence of 20-40%, associated with high cardiovascular mortality. Despite the association of type 2 diabetes (T2D) in young adults with rapid progression to DKD, in type 1 diabetes (T1D) this is not well established. Other complications have also a high impact on life quality.<p class="abstext...

Introduction: In addition to physiological causes, the hyperprolactinemia spectrum includes iatrogenesis, pituitary adenomas, various diseases and functional disorders. Hyperprolactinemia accurate etiological diagnosis is essential for appropriate treatment. Non-functioning pituitary incidentalomas occur in approximately 10% of the population and tiny microprolactinomas could be elusive to imaging by magnetic resonance (MRI). Therefore, the coincidence of hyperprolactinemia an...

Introduction: Cushing syndrome is a complex disease with multisystemic manifestations. It includes skin and connective tissue abnormalities, in which glucocorticoids reduce the synthesis and production of collagen, resulting in skin thinning, subcutaneous vascular tissue frailty and mucocutaneous bleeding. Case report: A 59-year-old woman with history of hypertension, type 2 diabetes, hypercholesterolemia, and chronic kidney disease, was admitted to the ...

Introduction: MUTYH (MutY homolog Escherichia coli, homolog of MYH, hMYH) is a repair enzyme with a crucial role in the correction of DNA errors, being considered a protective factor of the cell. MUTYH mutations have been linked to MUTYH-associated polyposis syndrome (MAP), an autosomal recessive disorder characterized by multiple colorectal adenomas. Patients with MAP show a much higher lifetime risk of gastrointestinal cancers as an additional role of MUTYH, it appears to co...

Introduction: Intra-thyroid metastases are infrequent, comprising only 1-3% of all thyroid malignancies. Renal cell carcinoma, particularly of the clear cell type (CCRC), stands out as the predominant kidney malignancy and the most common primary source of intra-thyroid metastases, often manifesting several years post-diagnosis. This report highlights two cases of CCRC metastasis to the thyroid, both featuring deceptive cytological findings.Case 1: A 60-...

Background and Objective: Semaglutide, a glucagon-like peptide 1 (GLP1a) receptor agonist, reduces the risk of major adverse cardiovascular events in patients with type 2 diabetes mellitus (DM2). An oral version of semaglutide is now available, and patients may prefer it to the subcutaneous form. Our objective was to compare the effectiveness and safety of both formulations in real life.Methods: Retrospective real-world efficacy analysis including aGLP1-...

Arterial hypertension is a major health problem affecting 1.13 billion people worldwide, of which 10% could be due to endocrine pathologies related to the mineralocorticoid receptor (MR) (i.e. primary aldosteronism, 11β-hydroxysteroid dehydrogenase type 2 enzyme (HSD11B2) deficiency). The MR pathway is expressed mainly in placenta, kidney and colon epithelial cells. Current research highlights potential epigenetic regulatory mechanisms for the MR pathway. Here, specific m...

Introduction: The prevalence of hypertension in children and adolescent who were extremely preterm newborns (EP; ≤32 gestational weeks) has been found to be higher than in those born at term. The causes have not been well characterized. Studies support that adrenal dysregulation might be a consequence of prematurity.Objectives: To determinate if children who were EP had higher adrenal hormones and vascular remodeling biomarker than term newborn (&#...

Objective: To compare 2 modalities of bolus-basal insulin therapy with aspart-detemir, according to the moment of administration of detemir (DET), before the lunch or bed-time, in type 1 diabetic patients with poor metabolic control.Methods: We conducted a prospective study of 40 type 1 diabetic patients, with poor metabolic control (HbAc 7–12%), randomized to receive treatment with 1 injection of DET before the lunch or bed-time and followed-up dur...